The questions that constitute the subject matter of this article are analyzed through three groups of questions and concluding remarks in which the basic findings reached in the professional-critical analysis of these questions are presented in the form of a summary.The first group of questions deals with general remarks about the environment and i

Interleukin-12 Milk Thistle (IL-12), produced by dendritic cells in response to activation, is central to pathogen eradication and tumor rejection.The trafficking pathways controlling spatial distribution and intracellular transport of IL-12 vesicles to the cell surface are still unknown.Here, we show that intracellular IL-12 localizes in late endo

Abstract Background An association of different autoimmune diseases is suspected.In juvenile idiopathic arthritis (JIA), only few and partially conflicting data on the co-existence Milk Thistle of other autoimmune disorders are available.The prevalence of autoantibodies in patients with JIA in Germany is not known.Methods Samples from 499 patients

Proprotein convertases are enzymes that proteolytically cleave protein precursors in the secretory pathway to yield functional proteins.Seven mammalian subtilisin/Kex2p-like proprotein convertases have been identified: furin, PC1, PC2, PC4, PACE4, PC5 and PC7.The binding pockets of all seven proprotein convertases are evolutionarily conserved and h